Only 1 single medication has been approved in the United States for treatment of HLH (emapalumab)
There are dozens of protocols for treating Cytokine Release Syndrome after CART therapy – but none that are known for specifically malignancy-associated HLH
| Status | Study Title | Locations | |
| 1 | Terminated | Pilot Study of Etoposide-based Therapy and Hematopoietic Cell Transplantation for Hemophagocytic Lymphohistiocytosis | Asan Medical Center, University of Ulsan College of Medicine Seoul, Korea, Republic of |
| 2 | Recruiting | Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still’s or SLE | UAB Hospital Birmingham, Alabama, United States University of Florida Gainesville, Florida, United States Boston Children’s Hospital Boston, Massachusetts, United States (and 41 more…) |
| 3 | Completed | Secondary Adult’s Hemophagocytic Lymphohistiocytosis and Innate Immunity | Assistance Publique Hopitaux de Marseille Marseille, France |
| 4 | Recruiting | Evaluation of the Safety and Efficacy of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis | Phoenix Children’s Hospital Phoenix, Arizona, United States University of California, Los Angeles Los Angeles, California, United States MedStar Georgetown Washington, District of Columbia, United States (and 13 more…) |
| 5 | Completed | A Study to Investigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still’s Disease (AOSD) Developing Macrophage Activation Syndrome/Secondary HLH (MAS/sHLH) | Cincinnati Children’s Hospital Cincinnati, Ohio, United States Hôpital Necker-Enfants Malades, Unité d’Immunologie-hématologie et Rhumatologie pédiatriques Paris, France IRCCS Ospedale Pediatrico, Bambino Gesù Rome, Italy (and 2 more…) |
| 6 | Recruiting | Rituximab Monotherapy for EBV-HLH and CAEBV | Zhao Wang Beijing, China |
| 7 | Unknown † | Establishing a COVID-19 Prospective Cohort for Identification of Secondary HLH | Department of nephrology, Klinikum rechts der Isar München, Bavaria, Germany |
| 8 | Unknown † | Ruxolitinib Combined With Dexamethasone for HLH | Yan Yue Beijing, Chaoyang District, China Yan Yue Beijing, China |
| 9 | Completed | A Pilot Study of Ruxolitinib in Secondary Hemophagocytic Syndrome | University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States |
| 10 | Not yet recruiting | Safety and Effectiveness of Cyclosporin in the Management of COVID19 ARDS Patients in Alexandria University Hospital | |